Testosterone Replacement Therapy (TRT): Clinical Foundations, Protocol Design, and Patient-Centered Management is an asynchronous, self-paced continuing education course for healthcare professionals seeking evidence-based training in the evaluation, initiation, and long-term management of testosterone therapy in adult patients. The course reviews testosterone physiology, the hypothalamic–pituitary–gonadal (HPG) axis, and diagnostic criteria for hypogonadism; builds proficiency in interpreting key hormone laboratories; and examines the pharmacology and pharmacokinetics of available testosterone delivery methods. Emphasis is placed on protocol design, dosing optimization, estradiol management, patient safety, and adverse-effect monitoring, with additional focus on counseling strategies, lifestyle considerations, and complex clinical scenarios such as fertility preservation and comorbid disease. Through case-based learning, participants develop the skills needed to provide ethical, patient-centered, and guideline-informed testosterone therapy within their scope of practice.

Overall Course Learning Outcomes

Upon successful completion of this course, participants will be able to:

- Explain the physiology of testosterone production and regulation within the hypothalamic–pituitary–gonadal (HPG) axis.
- Differentiate between primary, secondary, and functional hypogonadism using clinical presentation and laboratory data.
- Interpret testosterone, estradiol, SHBG, and related laboratory values to support evidence-based clinical decision-making.
- Evaluate testosterone delivery methods based on pharmacokinetics, patient preference, and safety considerations.
- Apply best-practice dosing strategies to optimize therapeutic outcomes while minimizing adverse effects.
- Assess estradiol physiology and manage estrogen-related symptoms without inappropriate suppression.
- Identify common and serious adverse effects of testosterone replacement therapy (TRT) and implement appropriate monitoring and risk-mitigation strategies.
- Integrate lifestyle, behavioral, and counseling strategies to enhance patient outcomes and treatment adherence.
- Formulate individualized TRT plans for special populations, including patients seeking fertility preservation and those with complex comorbidities.
- Demonstrate ethical, patient-centered, and guideline-informed clinical judgment in the management of testosterone therapy.