Clinical decision-making in complex patient care involves integrating diverse information from various sources to make informed choices that prioritize patient well-being. Clinicians must consider medical history, current symptoms, and potential interventions while collaborating with interdisciplinary teams. Effective decision-making also requires an understanding of psychosocial factors, ethical considerations, and patient preferences, ensuring that care is holistic and patient-centered. Continuous education and reflective practice are essential to adapt to evolving medical knowledge and practices, ultimately enhancing the quality of care provided to patients with complex needs.